Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project
1 Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany
2 National Physical Laboratory (NPL), Teddington, UK
3 EBG MedAustron GmbH, Wiener Neustadt, Austria
4 Istituto Nazionale di Metrologia delle Radiazioni Ioniszanti (ENEA-INMRI), Via Anguillarese, 301, 00123 Santa Maria di Galeria RM, Italy
5 Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France
6 Istituto Nazionale di Fisica Nucleare (INFN), Legnaro, Italy
7 Politecnico di Milano (PoliMi), Milan, Italy
8 National Centre for Nuclear Research (NCBJ), Otwock-Swierk, Poland
9 Universidade Tecnica de Lisboa, Instituto Tecnológico e Nuclear (IST-ITN), Sacavém, Portugal
a Corresponding author: email@example.com
Published online: 19 August 2014
Funded within the European Metrology Research Programme (EMRP) , the joint research project “Biologically weighted quantities in radiotherapy” (BioQuaRT)  aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.
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