Metrological Issues in Molecular Radiotherapy
1 National Institute of Ionizing Radiation Metrology, ENEA-INMRI, C.R. Casaccia, 00123 Rome, Italy
2 Department of Human Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Via Borelli 50, 00161 Rome, Italy
3 National Physical Laboratory NPL, Hampton Road, Teddington, Middlesex, TW11 0LW, UK
4 Czech Metrology Institute (CMI), Inspectorate for Ionising Radiation, Radiova 1, CZ-102 00 Prague 10, Czech Republic
5 Commissariat a l’Energie Atomique (CEA) Bt 476, Pt Courrier 142, CEA-Saclay, FR-91191 Gif-sur-Yvette Cedex, France
6 Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, D-38116 Braunschweig, Germany
7 VSL, Dutch Metrology Institute, Thijsseweg 11, P.O. Box 654, NL-2629, JA Delft, Netherlands
a Corresponding author: email@example.com
Published online: 19 August 2014
The therapeutic effect from molecular radiation therapy (MRT), on both tumour and normal tissue, is determined by the radiation absorbed dose. Recent research indicates that as a consequence of biological variation across patients the absorbed dose can vary, for the same administered activity, by as much as two orders of magnitude. The international collaborative EURAMET-EMRP project “Metrology for molecular radiotherapy (MetroMRT)” is addressing this problem. The overall aim of the project is to develop methods of calibrating and verifying clinical dosimetry in MRT. In the present paper an overview of the metrological issues in molecular radiotherapy is provided.
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