Upconversion nanoparticles: on the way from diagnostics to theranostics

Alla Generalova; Kristina Mironova; Natalya Sholina; Vasylina Rocheva; Andrey Nechaev; Ekaterina Grebenik; Anna Guller; Andrey Zvyagin; Sergey Deyev; Vitaly Zubov; Evgeny Khaydukov

doi:10.1051/epjconf/201819003001

All issues

Volume 190 (2018)

EPJ Web Conf., 190 (2018) 03001

Abstract

Open Access

Issue		EPJ Web Conf. Volume 190, 2018 XIII International Conference on Hole Burning, Single Molecule, and Related Spectroscopies: Science and Applications (HBSM-2018)


Article Number		03001
Number of page(s)		2
Section		Oral talks
DOI		https://doi.org/10.1051/epjconf/201819003001
Published online		26 September 2018

EPJ Web of Conferences 190, 03001 (2018)
https://doi.org/10.1051/epjconf/201819003001

Upconversion nanoparticles: on the way from diagnostics to theranostics

Alla Generalova¹^,2^*, Kristina Mironova¹^,2, Natalya Sholina³, Vasylina Rocheva², Andrey Nechaev⁴, Ekaterina Grebenik³^,5, Anna Guller⁵, Andrey Zvyagin⁵, Sergey Deyev¹, Vitaly Zubov¹ and Evgeny Khaydukov²^,3

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997, Moscow, Russia
² Scientific Research Centre “Crystallography and Photonics” RAS, 119333, Moscow, Russia
³ Sechenov First Moscow State Medical University, 119991 Moscow, Russia
⁴ Institute of Fine Chemical Technologies, 119571, Moscow Russia
⁵ Macquarie University, Sydney, NSW 2109, Australia

^* Corresponding author: a-generalova@yandex.ru

Published online: 26 September 2018

Abstract

We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF₄ codoped with Yb³⁺ and Er³⁺or Tm³⁺. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue “transparency window”, as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.

This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.