EPJ Web of Conferences
Volume 40, 2013JEMS 2012 – Joint European Magnetic Symposia
|Number of page(s)||4|
|Published online||14 January 2013|
Simulation of magnetic active polymers for versatile microﬂuidic devices
St. Poelten University of Applied Sciences, St. Poelten, Austria
2 AIT Austrian Institute of Technology, Vienna, Austria
a e-mail: firstname.lastname@example.org
We propose to use a compound of magnetic nanoparticles (20–100 nm) embedded in a ﬂexible polymer (Polydimethylsiloxane PDMS) to ﬁlter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnosis and monitoring of cancer. The combination of experiments and simulations lead to a versatile microﬂuidic lab-on-chip device. Simulations are essential to understand the inﬂuence of the embedded nanoparticles in the elastic PDMS when applying a magnetic gradient ﬁeld. It combines ﬁnite element calculations of the polymer, magnetic simulations of the embedded nanoparticles and the ﬂuid dynamic calculations of blood plasma and blood cells. With the use of magnetic active polymers a wide range of tunable microﬂuidic structures can be created. The method can help to increase the yield of needed isolated CTCs.
© Owned by the authors, published by EDP Sciences, 2013
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.