| Issue |
EPJ Web of Conferences
Volume 40, 2013
JEMS 2012 – Joint European Magnetic Symposia
|
|
|---|---|---|
| Article Number | 02001 | |
| Number of page(s) | 4 | |
| Section | Biomagnetism | |
| DOI | https://doi.org/10.1051/epjconf/20134002001 | |
| Published online | 14 January 2013 | |
https://doi.org/10.1051/epjconf/20134002001
Simulation of magnetic active polymers for versatile microfluidic devices
1
St. Poelten University of Applied Sciences, St. Poelten, Austria
2
AIT Austrian Institute of Technology, Vienna, Austria
a e-mail: markus.gusenbauer@fhstp.ac.at
We propose to use a compound of magnetic nanoparticles (20–100 nm) embedded in a flexible polymer (Polydimethylsiloxane PDMS) to filter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and clinical cancer management including the detection, diagnosis and monitoring of cancer. The combination of experiments and simulations lead to a versatile microfluidic lab-on-chip device. Simulations are essential to understand the influence of the embedded nanoparticles in the elastic PDMS when applying a magnetic gradient field. It combines finite element calculations of the polymer, magnetic simulations of the embedded nanoparticles and the fluid dynamic calculations of blood plasma and blood cells. With the use of magnetic active polymers a wide range of tunable microfluidic structures can be created. The method can help to increase the yield of needed isolated CTCs.
© Owned by the authors, published by EDP Sciences, 2013
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