EPJ Web of Conferences
Volume 41, 2013XVIIIth International Conference on Ultrafast Phenomena
|Number of page(s)||3|
|Published online||13 March 2013|
pH jump induced α-helix folding.
University of Zurich, Institute of Physical Chemistry, Winterthurerstrasse 190 CH-8057 Zurich, Switzerland
pH can be used to impact the folding equilibrium of peptides and proteins. This fact is utilized, similarly to temperature jumps, in pH jump experiments employing laser time-resolved spectroscopy to study the function and structural dynamics of these molecules. Here the application of pH jumps in folding experiments was investigated. Experiments with poly-L-glutamic acid alpha-helix formation shown the critical aspects of pH jump experiments and yielded direct information about the folding kinetics monitored with the amide I IR band.
© Owned by the authors, published by EDP Sciences, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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