| Issue |
EPJ Web of Conferences
Volume 83, 2015
QENS/WINS 2014 - 11th International Conference on Quasielastic Neutron Scattering and 6th International Workshop on Inelastic Neutron Spectrometers
|
|
|---|---|---|
| Article Number | 02011 | |
| Number of page(s) | 5 | |
| Section | QENS 2014 | |
| DOI | https://doi.org/10.1051/epjconf/20158302011 | |
| Published online | 23 January 2015 | |
https://doi.org/10.1051/epjconf/20158302011
Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
1 Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark
2 Instituto de Biociências - Universidade Estadual Paulista – CP. 510, 18618-970 Botucatu – SP, Brazil
3 Institut Laue-Langevin, BP. 156, 38042 Grenoble, France
4 Dipartimento di Fisica, Università di Perugia, 06123 Perugia, Italy
5 Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden
6 Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, Florida 33620, USA
7 Laboratory for Neutron Scattering, Paul Scherrer Institute, 5232 Villigen, Switzerland
a e-mail: murillolongo@gmail.com
b e-mail: bordallo@nbi.ku
Published online: 23 January 2015
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.