EPJ Web Conf.
Volume 140, 2017Powders and Grains 2017 – 8th International Conference on Micromechanics on Granular Media
|Number of page(s)||4|
|Published online||30 June 2017|
Experimental study of tensile strength of pharmaceutical tablets: effect of the diluent nature and compression pressure
1 Univ Lyon, Universite Lyon 1, CNRS, UMR5007, LAGEP, 43 bd du 11 Novembre 1918, F-69622 LYON, France
2 LGPM, CentraleSupélec, Université Paris-Saclay, Grande Voie des Vignes, 92295 Châtenay-Malabry, France
3 Univ Lyon, Ecole Centrale de Lyon, LTDS UMR CNRS 5513, 36 avenue Guy de Collongue, F-69134 ECULLY cedex, France
Published online: 30 June 2017
In the pharmaceutical field, tablets are the most common dosage form for oral administration in the world. Among different manufacturing processes, direct compression is widely used because of its economics interest and it is a process which avoids the steps of wet granulation and drying processes. Tablets are composed of at least two ingredients: an active pharmaceutical ingredient (API) which is mixed with a diluent. The nature of the powders and the processing conditions are crucial for the properties of the blend and, consequently, strongly influence the mechanical characteristics of tablets. Moreover, tablets have to present a suitable mechanical strength to avoid crumbling or breaking when handling, while ensuring an appropriate disintegration after administration. Accordingly, this mechanical property is an essential parameter to consider. Experimental results showed that proportion of the diluent, fragmentary (DCPA) or plastic (MCC), had a large influence on the tensile strength evolution with API content as well as the compression load applied during tableting process. From these results a model was developed in order to predict the tensile strength of binary tablets by knowing the compression pressure. The validity of this model was demonstrated for the two studied systems and a comparison was made with two existing models.
© The Authors, published by EDP Sciences, 2017
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