EPJ Web Conf.
Volume 225, 2020ANIMMA 2019 – Advancements in Nuclear Instrumentation Measurement Methods and their Applications
|Number of page(s)||5|
|Section||Environmental and Medical Sciences|
|Published online||20 January 2020|
MAPSSIC, a communicating MAPS-based intracerebral positrons probe for deep brain imaging in awake and freely-moving rats
Aix Marseille Univ, CNRS/IN2P3, CPPM,
M. Bautista, F. Gensolen, P. Pangaud, and C. Morel are with the Aix Marseille Univ, CNRS/IN2P3, CPPM, Marseille, France.
L. Ammour, F. Lefebvre, L. Pinot, P. Laniece and M-A Verdier are with the Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC), CNRS, Univ Paris Sud, Université Paris-Saclay, F-91406 Orsay, France.
L. Ammour, F. Lefebvre, L. Pinot, P. Laniece and M-A Verdier are with Université de Paris, IMNC, F-91400 Orsay, France
J. Heymes, M. Kachel, and J. Baudot are with the Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France.
S. Fieux and L. Zimmer are with the CERMEP-Imagerie du vivant, Université Claude Bernard Lyon 1, CNRS, INSERM, Hospices Civils de Lyon, Lyon, France.
P. Gisquet-Verrier is with the NeuroPSI CNRS/INSB, Univ Paris Sud, Orsay, France.
Published online: 20 January 2020
Radioisotope imaging is a powerful tool to understand the biological mechanisms in-vivo, especially in the brain of small animals, providing a significant model to study the human brain.
In this context, we have developed and built a pixelated intracerebral positron probe to be embedded on awake and freely moving small animals, typically rats. This pixelated probe will represent a key instrument for neuroscientists to study neural mechanisms and correlate them to behavioral experiments.
We describe in this paper the simulations carried out to design the intracerebral sensor, its architecture, and the detection of positrons in a volume with a couple of sensors assembled back-to-back. We also depict the architecture of the wireless acquisition system. Finally, we present the first measurements performed in real-time by this miniaturized probe with sealed radioactive sources and a 18F solution.
Key words: Active pixel sensors / Animal behavior / CMOS Image sensors / Implants / Molecular imaging / Monte Carlo methods / Nuclear Imaging / Positron emission tomography
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.