A microfluidic chip for generation a lipid phase in an aqueous dispersion

¹ Department of Physical Measurements, Institute for Nanomaterials, Advanced Technologies and Innovation, 46117 Liberec, Czech Republic
² Grade Medical s.r.o., 159 00 Prague 5 – Lahovice, Czech Republic
³ Faculty of Mechatronics, Informatics and Interdisciplinary Studies, 46117 Liberec, Czech Republic

^* Corresponding author: darina.jasikova@tul.cz

Published online: 4 July 2024

Abstract

The subject of study involves the handling of liquids and gases in the order of micro-litres and in micro scale resolution. Microfluidic structures are very fine in the context of the macro world, and standard dimensions are around 100 µm, but even finer, depending on the manufacturing process. Visualization are used to study events and processes inside microstructures. Events taking place in fine structures are influenced by parameters such as liquid resistance, interfacial forces, diffusion transfer of molecules and mutual interactions both at the chemical and thermodynamic levels. The analysis of the behaviour of liquids in microfluidic systems involves a change of approach in deriving the influence of input conditions on the resulting behaviour and the course of interactions both between the wall of the structure and the liquid, but also in the liquid itself. The methodology and production of a microfluidic device usually uses a number of technologies. The process often combines a lithographic technique with a controlled etching or laser engraving method. This article introduces the initial experiments with droplet microfluidic generators, which took place at TUL - CXI and subsequently led to the construction of your own implementation in the form of a capillary chip that can be used in pharmacy.