| Issue |
EPJ Web Conf.
Volume 309, 2024
EOS Annual Meeting (EOSAM 2024)
|
|
|---|---|---|
| Article Number | 04009 | |
| Number of page(s) | 2 | |
| Section | Topical Meeting (TOM) 4- BioPhotonics and Biosensors | |
| DOI | https://doi.org/10.1051/epjconf/202430904009 | |
| Published online | 31 October 2024 | |
https://doi.org/10.1051/epjconf/202430904009
Gold nanoparticles and near-infrared light as a new tool to enhance tissue regeneration
1 Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, CNR, Pozzuoli, Italy
2 Istituto di Bioscienze e Biorisorse, CNR, Napoli, Italy
3 Istituto de Nanociencia y Materiales de Aragón (INMA), Zaragoza, Spain
* Corresponding author: valentina.marchesano@cnr.it
Published online: 31 October 2024
Controlled temperature elevation within biological tissues, known as hyperthermia, holds promise as a therapeutic treatment. Its efficacy depends on several factors including timing, pulsing, and repetition. Recent research indicates the potential of heat-based therapies not only for cancer treatment but also in tissue regeneration. The usage of photothermal agents, such as gold nanoparticles, enables precise spatio-temporal heat generation, known as photothermal therapy (PTT). Hydra vulgaris, with their unique regenerative capabilities, serve as valuable models for exploring the effects of nanoparticles on tissue regeneration. AuNPs thanks to their plasmonic properties can induce physiological responses in the animals under near-infrared (NIR) irradiation, ranging from cell ablation to programmed cell death or thermotolerance. By tuning the NIR irradiation and the AuNPs dose, the capability of treated polyps to regenerate the missing heads under photostimulation will be dissected, at whole animal, cellular and molecular levels and compared to exposure to external macroscopic heat sources.
© The Authors, published by EDP Sciences, 2024
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