Issue |
EPJ Web Conf.
Volume 309, 2024
EOS Annual Meeting (EOSAM 2024)
|
|
---|---|---|
Article Number | 04025 | |
Number of page(s) | 2 | |
Section | Topical Meeting (TOM) 4- BioPhotonics and Biosensors | |
DOI | https://doi.org/10.1051/epjconf/202430904025 | |
Published online | 31 October 2024 |
https://doi.org/10.1051/epjconf/202430904025
Towards enhanced cancer therapy; Leveraging bioresorbable optical fibers for improved treatment outcomes
1 Fondazione LINKS-Leading Innovation and Knowledge for Society, via P. C. Boggio 61, 10138 Torino, Italy
2 Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
3 SpectraCure AB, Gasverksgatan 1, SE-222 29 Lund, Sweden
4 Department of Physics, Lund University, P.O. Box 118, SE-221 00 Lund, Sweden
5 ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss, 3, 08660 Castelldefels (Barcelona), Spain
* Corresponding author: jawad.talekkara@polito.it
Published online: 31 October 2024
Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate (CaP) glass for diffuse correlation spectroscopic (DCS) and diffuse fluorescence tomographic (DFT) applications. The results represent the potential of bioresorbable fibers for the monitoring of interstitial microvascular blood flow and the spatial distribution of fluorescent photosensitizer drugs that are administered prior to therapies. Together or separate, the continuous monitoring of these parameters can have significant implications in planning, optimizing and in predicting or monitoring the outcomes in interstitial photodynamic therapy (PDT).
© The Authors, published by EDP Sciences, 2024
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