| Issue |
EPJ Web Conf.
Volume 345, 2026
4th International Conference & Exposition on Materials, Manufacturing and Modelling Techniques (ICE3MT2025)
|
|
|---|---|---|
| Article Number | 01075 | |
| Number of page(s) | 8 | |
| DOI | https://doi.org/10.1051/epjconf/202634501075 | |
| Published online | 07 January 2026 | |
https://doi.org/10.1051/epjconf/202634501075
Indirect spectrophotometric estimation of lidocaine using crystal violet
1 Department of Chemistry, College of Education for Women, Tikrit University, Tikrit, Iraq
2 Department of Pharmaceutical Chemistry, College of Pharmacy, Tikrit University, Tikrit, Iraq
* Corresponding author: sura.ibrahim23@st.tu.edu.iq
Published online: 7 January 2026
A simple, quick and perceptive method was developed to estimate Lidocaine in its pure and pharmaceutical forms spectrally using a spectrometer for ultraviolet visible rays, and the method was summarized: by oxidation of the drug using a mixture of bromate and potassium bromide KBr-KBrO3 with an acidic medium, where the remaining oxidizing agent reacts with the dye Crystal violet (CV) to be a dark blue product It gave peak absorption value at 612 nm, with Beer-lambert law (linear concentration) was between (15) and (100) μg/ml while the molar absorption coefficient was equal to (1945.022) L/mol/cm , limit of detection (0.36) μg/ml, while the quantity limit was (1.08) μg/ml. The method has been effictively applied to the measurement of Lidocaine in both its pure form and its pharmaceutical preparations.
© The Authors, published by EDP Sciences, 2026
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