EPJ Web of Conferences
Volume 83, 2015QENS/WINS 2014 - 11th International Conference on Quasielastic Neutron Scattering and 6th International Workshop on Inelastic Neutron Spectrometers
|Number of page(s)||6|
|Published online||23 January 2015|
High-resolution neutron spectroscopy on protein solution samples
1 Institut Max von Laue - Paul Langevin (ILL), CS20156, 38042 Grenoble, France
2 Institut für Angewandte Physik, University of Tübingen, 72076 Tübingen, Germany
3 Jülich Centre for Neutron Science JCNS, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany
4 JCNS Outstation at the Spallation Neutron Source, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6475, USA
5 Max-Planck Institute for Developmental Biology, Spemannstraße 35, 72076 Tübingen, Germany
a e-mail: email@example.com
Published online: 23 January 2015
Proteins in solution move subject to a complex superposition of global translational and rotational diffusion as well as internal relaxations covering a wide range of time scales. With the advent of new high-flux neutron spectrometers in combination with enhanced analysis frameworks it has become possible to separate these different contributions. We discuss new approaches to the analysis by presenting example spectra and fits from data recorded on the backscattering spectrometers IN16, IN16B, and BASIS on the same protein solution sample. We illustrate the separation of the rotational and translational diffusion contribution, the accurate treatment of the solvent contribution, and the extraction of information on internal fluctuations. We also exemplify the progress made in passing from second- to third-generation backscattering spectrometers.
© Owned by the authors, published by EDP Sciences, 2015
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