| Issue |
EPJ Web Conf.
Volume 335, 2025
EOS Annual Meeting (EOSAM 2025)
|
|
|---|---|---|
| Article Number | 04002 | |
| Number of page(s) | 2 | |
| Section | Topical Meeting - BioPhotonics and Biosensors | |
| DOI | https://doi.org/10.1051/epjconf/202533504002 | |
| Published online | 22 September 2025 | |
https://doi.org/10.1051/epjconf/202533504002
Detection and characterization of exosomes via a polystyrene-coated silica microresonator
General and Theoretical Electrical Engineering (ATE), University of Duisburg-Essen (UDE), and Center for Nanointegration Duisburg-Essen (CENIDE), D-47048 Duisburg, Germany
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Published online: 22 September 2025
Abstract
Exosomes are promising biomarkers for early-stage cancer diagnostics. We present a lab-on-chip biosensor capable of detecting and characterizing single exosomes using a 30 µm silica microresonator coated with a tailored polystyrene nanoshell. The shell enhances the microresonator’s sensitivity, enabling not only single-exosome detection but also characterization based on protein content relevant to cancer diagnostics. Simulation results show that the polystyrene coating increases the resonance wavelength shift by 52% in the presence of an exosome, allowing the detection of subtle variations in protein composition.
© The Authors, published by EDP Sciences, 2025
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