Chemistry and biomedical relevance of pyrazole derivatives: An integrated review

¹ Department of Chemistry, School of Science, RK University, Rajkot, India
² DKV Arts and Science College, Saurashtra University, Jamnagar, India

^* Corresponding author:This email address is being protected from spambots. You need JavaScript enabled to view it.

Published online: 21 January 2026

Abstract

Over the past decades, the interest in the synthesis and applications of different pyrazole derivatives has been increased dramatically. Pyrazole is well known five-member ring found to be present in many plants and microorganisms. Due to its ability to binding with cell receptor as well as enzymes, pyrazole scaffold is gaining much attention of scientist. In last few years, a large number of synthesis method and its applications in different fields highlight its important in research. The literature survey shows that pyrazole scaffold possess various pharmacological and biological activity and due to its versatile structure make it more convenient to design new leading molecules. The aim of review is to give comprehensive overview on the pyrazole scaffold; synthesis, biological study and synthetic approaches.