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All issues Volume 348 (2026) EPJ Web Conf., 348 (2026) 02004 References
Open Access
Issue
EPJ Web Conf.
Volume 348, 2026
3rd International Conference on Innovations in Molecular Structure & Instrumental Approaches (ICMSI 2026)
Article Number 02004
Number of page(s) 20
Section Chemistry
DOI https://doi.org/10.1051/epjconf/202634802004
Published online 21 January 2026
  1. K. Emrunal, M. Uzzaman, A review on biological and medicinal impact of heterocyclic compounds. Results in Chem., 4 (2022). [Google Scholar]
  2. H. B. HUnagund, A Study on synthesis and biological activities of novel heterocyclic compounds, Int. J. Res. Pub. Review. 5(7), 1151 (2024). [Google Scholar]
  3. D. K. Slman, H. A. Satar, Z. A. Ketan, A. A. Jawad, Heterocyclic Compounds: A Study of its Biological Activity. Al-Nahrain J. Sci., 2, 27 (2024). [Google Scholar]
  4. M. M. Li, X. Chenb, Y. Deng, J. Lu, Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity. RSCAdv. 11, 38060 (2021). [Google Scholar]
  5. A. Mohammad, M. A. Raza, K. Javed, S. Mohd. N. Islam, M. Farhan, M. W. Alam, Potential nitrogen-based heterocyclic compounds for treating infectious diseases: a literature review. Antibiotics 11, 1750 (2022). [Google Scholar]
  6. G. Li, Y. Cheng, C. Han, C. Song, N. Huang, Y. Du, Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies. RSC Med Chem. 26, 13(11), 1300–1321 (2022). [Google Scholar]
  7. L. Knorr, Action of ethyl acetoacetate on phenylhydrazine. I". ChemischeBerichte. 16, 2597–2599 (1883). [Google Scholar]
  8. F. Blanco, I. Alkorta, K. Zborowski, J. Elugero, Substitution effects in N-pyrazole and N-imidazole derivatives along the periodic table. Struct Chem. 18, 965–975 (2007). [Google Scholar]
  9. S. Tayyaba, M. Ghulam, Z. Wardha, H. Abrar, S. H. Sumrra, A. Awais, Pyrazoles a privileged scaffold in drug discovery - Synthetic strategies & exploration of pharmacological potential. J. Mol. Structure. 1348(2), 143523 (2025). [Google Scholar]
  10. N. Devi, R. Shankar, V. Singh, 4-Formyl-Pyrazole-3-Carboxylate: a useful aldoxbifunctional precursor for the syntheses of pyrazole-fused/substituted frameworks. J. Het. Chem. 55, 378 (2018). [Google Scholar]
  11. K. Karrouchi, S. Radi, Y. Ramli, J. Taoufik, Y. Mabkhot, F. Al-aizari, M. Ansar, M. Synthesis and pharmacological activities of pyrazole derivatives: a review. Molecules 23, 134 (2018). [Google Scholar]
  12. F. E. Bennani, L. Doudach, Y. Cherrah, Y. Ramli, K. Karrouchi, M. Ansar, M. E. A. Faouzi, Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line. Bioorganic Chem. 97, 103470 (2020). [Google Scholar]
  13. A. Ansari, A. Ali, M. Asif, S. Shamsuzzaman, Review: Biologically active pyrazole derivatives. New J. Chem. 41, 16 (2017). [Google Scholar]
  14. S. Fustero, M. Sánchez-Roselló, P. Barrio, A. Simön-Fuentes, from 2000 to Mid-2010: A fruitful decade for the synthesis of pyrazoles. Chem. Rev. 111, 6984–7034 (2011). [Google Scholar]
  15. K. Karrouchi, S. Radi, Y. Ramli, J. Taoufik, Y. Mabkhot, F. Al-aizari, M. Ansar, Synthesis and pharmacological activities of pyrazole derivatives: a review, molecules, 23, 134, (2018). [Google Scholar]
  16. K. Karrouchi, S. Mortada, N. Issaoui, O. El-guourrami, S. Arshad, M. Bouatia, A. Sagaama, H. Benzeid, M/E. Karbane, M.E. A.Faouzi, Synthesis, crystal structure, spectroscopic, antidiabetic, antioxidant and computational investigations of ethyl 5-hydroxy-1-isonicotinoyl-3-methyl-4, 5-dihydro-1H-pyrazole-5-carboxylate. J. Mol. Struct., 1251, 131977 (2022). [Google Scholar]
  17. Y. Meng, T. Zhang, X. Gong, M. Zhang, C. Zhu, Visible-light promoted one-pot synthesis of pyrazoles from alkynes and hydrazines. Tetrahedron Lett. 60, 171–174, (2019). [Google Scholar]
  18. F. E. Bennani, L. Doudach, Y. Cherrah, Y Ramli, K. Karrouchi, M. Ansar, M. E. A. Faouzi, Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line. Bioorganic Chem., 97, 103470 (2020). [Google Scholar]
  19. A. Ansari, A. Ali, M. Asif, S. Shamsuzzaman, Review: biologically active pyrazole derivatives. New J. Chem., 41, 16–41 (2017). [Google Scholar]
  20. S. Fustero, M. Sanchez-Rosellö, P. Barrio, A. Simön-Fuentes, From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles. Chem. Rev., 111, 6984–7034 (2011). [Google Scholar]
  21. A. O. Abeed, T. I. El-Emary, M. K. Youssef, A facile synthesis and reactions of some novel pyrazole-based heterocycles. Current Org. Syn. 16(3), 405-412, 2019. [Google Scholar]
  22. M. M. F. Ismail, A. Farrag, M. F. Harras, Novel 1, 3, 4-triaryl pyrazoles: synthesis, qsar studies and cytotoxicity against breast cancer. anticancer agent in med. Chem. 19 (2019). [Google Scholar]
  23. M. Sankaran, C. Uvarani, K. Chandraprakash, M. U. Maheswari, P. S. Mohan, An expedient approach for the synthesis of bioactive pyrazole, isoxazole and benzodiazepine-substituted quinolin-2(1H)-one derivatives. J. Heterocycl. Chem., 52, 1082–1092 (2015). [Google Scholar]
  24. N. C. Desai, G. M. Kotadiya, A. R. Trivedi, V. M. Khedkar and P. C. Jha, Design, synthesis, and biological evaluation of novel □uorinated pyrazole encompassing pyridyl 1, 3, 4- oxadiazole motifs. Med. Chem. Res., 25, 2698–2717 (2016). [Google Scholar]
  25. T. Arasakumar, S. Mathusalini, S. Gopalan, S. Shyamsivappan, A. Ata and P. S. Mohan, Biologically active perspective synthesis of heteroannulated 8- nitroquinolines with green chemistry approach, Bioorg. Med. Chem. Lett. 27, 1538–1546 (2017). [Google Scholar]
  26. L. H. Al-Wahaibi, M. A. I. Elbastawesy, N. E. Abodya, B. G. M. Youssif, S. Brase, S. N. Shabaan, G. H. Sayed and K. E. Answer, New pyrazole/pyrimidine-based scaffolds as inhibitors of heat shock protein 90 endowed with apoptotic anti-breast cancer activity, Pharmaceuticals. 17, 1284 (2024). [Google Scholar]
  27. G. M. Nitulescu, L. Matei, I. M. Aldea, C. Draghici, O. T. Olaru and C. Bleotu, Ultrasound-assisted synthesis and anticancer evaluation of new pyrazole derivatives as cell cycle inhibitors. Arabian J. Chem. 12, 816–824 (2019). [Google Scholar]
  28. P. A. Datar, S. R. Jadhav, Design and synthesis of pyrazole-3-one derivatives as hypoglycaemic agents. Int. J. Med Chem. 670181 (2015). [Google Scholar]
  29. N. Kaushik, N. Kumar, A. Kumar, Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole, Ind. J. Pharma. 352 (2016). [Google Scholar]
  30. A. Barakat, A. M. Al-Majid, B. M. Al-Qahtany, M. Ali, M. Teleb, M. H. Al Agamy, S. Naz, Z. Ul-Haq, Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures. Chem. Cent J. 14, 12(1), (2018). [Google Scholar]
  31. S. Mortada, K. Karrouchi, E. H. Hamza, Synthesis, structural characterizations, in vitro biological evaluation and computational investigations of pyrazole derivatives as potential antidiabetic and antioxidant agents. Sci. Rep. 14, 1312 (2024). [Google Scholar]
  32. A. Ahmed, S. Zaib, M. A. Bhat, A. Saeed, M. Z. Altaf, F. T. Zahra, G. Shabir, N. Rana, I. Khan, I, Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis. Front. Chem. 12, 1380523 (2024). [Google Scholar]
  33. Naglah, Ahmed M., Abdulrahman A. Almehizia, Asma S. Al-Wasidi, Amirah SenaitanAlharbi, Mohammed H. Alqarni, Ashraf S. Hassan, and Wael M. Aboulthana, Exploring the potential biological activities of pyrazole-based schiff bases as anti-diabetic, anti-alzheimer's, anti-inflammatory, and cytotoxic agents: in vitro studies with computational predictions. Pharmaceuticals, 17, 5, 655 (2024). [Google Scholar]
  34. S. Gomha, K. Khalil, H. Abdel-aziz, M. Abdalla, Synthesis and anti-hypertensive a-blocking activity evaluation of thiazole derivatives bearing pyrazole moiety, heterocycles. 91, 9 (2015). [Google Scholar]
  35. G. N. Raju, J. R. Babu, M. B. Naik, K. Lakshmi, R. Rao Nadendla, Synthesis, characterization and biological evaluation pyrazole derivatives containing indole ring as a potent analgesic and anti-inflammatory agents, Der Pharma Chemica. 8(4), 301–309 (2016). [Google Scholar]
  36. A. K. Dhingra, B. Chopra, R. Dass, S. K. Mittal, Synthesis and anti-inflammatory activity of some o-propargylated-n-acetylpyrazole derived from 1, 3-diarylpropenones. Int. J. Med Chem. 3156593 (2016). [Google Scholar]
  37. V. W. Y. Liao, A. Kumari, R. Narlawar, S. Vignarajan, D. E. Hibbs, D. Panda and P. W. Groundwater, Tubulinbinding 3, 5-bis(styryl)pyrazoles as lead compounds for the treatment of castration-resistant prostate cancer, Mol. Pharmacol., 97, 409–422 (2020). [Google Scholar]
  38. D. Ashok, K. Padmavati, B. Vijayalakshmi, B. Sarasija, Microwave-assisted one-pot synthesis of pyrazolyl-substituted benzochroman-4-one derivatives and evaluation of their anticancer activity, Chem. Heterocycl. Compd., 52, 15 (2016). [Google Scholar]
  39. S. M. H. Sanad and A. E. M. Mekky, New thieno[2, 3-b]pyridine-fused pyrimidin-4(3H)-ones as potential hymidylate synthase inhibitors: Synthesis, SAR, in vitro and in silico study, J. Mol. Struct., 1282, 135236 (2023). [Google Scholar]
  40. K. M. Pandya, A. H. Patel, P. S. Desai, Development of antimicrobial, anti-malarial and antitubercular compounds based on a quinolinepyrazole clubbed scaffold derived via Doebner reaction. Chem. Afr. 3, 89–98 (2020). [Google Scholar]
  41. Y. R. Girish, K. S. S. Kumar, H. S. Manasa, S. Shashikanth, ZnO: an ecofriendly, green nano-catalyst for the synthesis of pyrazole derivatives under Aqueous Media. J. Chin. Chem. Soc., 61, 1175–1179 (2014). [Google Scholar]
  42. Y. Ohtsuka, D. Uraguchi, K. Yamamoto, K. Tokuhisa, T. Yamakawa, Syntheses of 2-(trifluoromethyl)-1, 3-dicarbonyl compounds through direct trifluoromethylation with CF3I and their application to fluorinatedpyrazoles syntheses. Tetrahedron, 68, 2636–2649 (2012). [Google Scholar]
  43. F. Gosselin, P. D. O Shea, R. A. Webster, R. A. Reamer, R. D. Tillyer, E. J. J. Grabowski, Highlyregioselective synthesis of 1-aryl-3, 4, 5-substituted pyrazoles. Synlett, 19, 3267–3270 (2006). [Google Scholar]
  44. J. E. Baldwin, G. J. Pritchard, R. E Rathmell, the reactions of diacetylenic ketones with nitrogen nucleophiles; facile preparation of alkynyl substituted pyrimidines and pyrazoles. J. Chem. Soc. Perkin Trans. 1, 2906–2908 (2001). [Google Scholar]
  45. G. Ji, X. Wang, S. Zhang, Y. Xu, Y. Ye, M. Li, Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of a, ß-alkynichydrazones using a hypervalent iodine reagent. Chem. Commun., 50, 4361–4363 (2014). [Google Scholar]
  46. B. C. Bishop, K. M. Brands, A. D. Gibb, D. J. Kennedy, Regioselective synthesis of 1, 3, 5-substituted pyrazoles from acetylenic ketones and hydrazines. Synthesis, 2004, 43–52 (2004). [Google Scholar]

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