| Issue |
EPJ Web Conf.
Volume 287, 2023
EOS Annual Meeting (EOSAM 2023)
|
|
|---|---|---|
| Article Number | 03013 | |
| Number of page(s) | 2 | |
| Section | Topical Meeting (TOM) 3- Biophotonics | |
| DOI | https://doi.org/10.1051/epjconf/202328703013 | |
| Published online | 18 October 2023 | |
https://doi.org/10.1051/epjconf/202328703013
Diffuser-based fiber endoscopy for single-shot 3D fluorescence imaging
1 Laboratory of Measurement and Sensor System Technique, TU Dresden
2 Competence Center for Biomedical Computational Laser Systems (BIOLAS), TU Dresden
3 Else Kröner Fresenius Center for Digital Health (EKFZ), TU Dresden
4 Cluster of Excellence Physics of Life, TU Dresden
* e-mail: tom.glosemeyer@tu-dresden.de
Published online: 18 October 2023
Minimally invasive endoscopy using coherent fiber bundles shows great potential for numerous applications in biomedical imaging. With a diffuser on the distal side of the fiber bundle and computational image recovery, single-shot 3D imaging is possible by encoding the image volume into 2D speckle patterns. In comparison to equivalent lens systems, a higher space-bandwidth product can be achieved. However, decoding the image with iterative algorithms is time-consuming. Thus, we propose utilizing a neural network for fast 2D and 3D image reconstruction at video rate. In this work, single-shot 3D fluorescence imaging with an ultra-thin endoscope is demonstrated, enabling applications like calcium imaging for in vivo brain diagnostics at cellular resolution.
© The Authors, published by EDP Sciences, 2023
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